GENtle

GENtle is a software for DNA and amino acid editing, database management, plasmid maps, restriction and ligation, alignments, sequencer data import, calculators, gel image display, PCR, and much more.
It is free software under GPLv2+ (source code is here).

Download

Windows (1.9.4) : GENtleSetup.exe (~2.7 MB)
Mac (1.9.4) : GENtle.pkg.zip (~3.7 MB) [PPC, but runs well on Intel under Rosetta]

Linux (1.9.3) : Now as package (thanks Steffen Möller!) for Ubuntu and Debian!
Otherwise : GENtle.tar.gz (~1.7 MB)

Needs wxGTK, sqlite, sqlite3, and mysqlclient installed
Ubuntu : sudo apt-get install libsqlite0 libsqlite3-0 libwxgtk2.6-0 libmysqlclient14
You can compile the current version yourself from CVS (as described here).
If you manage to generate a real binary Linux package, please let me know!

Documentation

Online manual at WikiBooks
Release notes
Doxygen source documentation (can be automatically generated from the source files)
German manual (PDF, ~1.5MB), last update 2004-09-29

Contact

GENtle is developed and maintained by Magnus Manske at the University of Cologne, Germany

Email : magnusmanske+gentlegooglemail.com

Screenshots

Click the preview icon to see the larger image.

DNA editor	PCR-Simulation and primer design	View and edit sequencer data	Protein analysis, secondary structure prediction etc.
Restriction editor	Internal or MySQL database	Alignments	Specialized calculators
Graph/spectra analysis		PHYLIP interface

Changelog

Current changelog is here!
Old changelog:

2005-07 Many bugfixes, graph/spectra module, PHYLIP interface, Mac OSX version
2005-02 Automatic annotation (V1.6)
2005-01 Peptide-to-DNA backtranslation for different codon usages; sqlite3-support for storing very long sequences
2004-12 Integrated BLAST and ClustalW functions that run in the background; working Linux version
2004-11 Integrated NCBI query, sequencing primers etc.
2004-08 Global enzyme settings, methylation, color coding etc.
2004-07 Genome mode speedup
2004-06 horizontal ABI mode
2004-05 insert restriction sites in PCR
2004-04 backtranslate DNA from amino acid sequence
16. März 2004: Bugfixes, Sekundärstrukturvorhersage für Proteine
06. Januar 2004 : Diverse Bugfixes, verbesserte Alignment-Funktion
05. November : Diverse Bugfixes, SilMut-Funktion im PCR-Modul, Undo-Funktion
02. September : AutoUpdate, Aminosäure-Offset-Anzeige
26. August : Protease-Verwaltung und -Darstellung
14. August :

integrierter Bildbetrachter für BioRad IMG-Format (provisorisch)
integrierter Rechner für Ligationsansätze und DNA-Konzentrationsbestimmung

24. Juli 2003: Erste Version

Impressum